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Article

Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani.

The Journal of biological chemistry - 29 Mar 2013

Boitz Jan M, Strasser Rona, Yates Phillip A, Jardim Armando, Ullman Buddy

Abstract excerpt

Leishmania are auxotrophic for purines, and consequently purine acquisition from the host is a requisite nutritional function for the parasite. Both adenylosuccinate synthetase (ADSS) and adenylosuccinate lyase (ASL) have been identified as vital components of purine salvage in Leishmania donovan...

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Identifiers

PMID: 23404497
DOI: 10.1074/jbc.M112.431486
PMCID: PMC3610970

Genes

ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23404497-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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