Article
Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani.
Molecular and biochemical parasitology - 1 Mar 2004
Zarella-Boitz Jan M, Rager Nicolle, Jardim Armando, Ullman Buddy
Abstract excerpt
The subcellular location of a protein is a critical factor in its physiological function and an important consideration in therapeutic paradigms that target the protein. Because Leishmania donovani cannot synthesize purine nucleotides de novo, they rely predominantly upon therapeutically germane...
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