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Article

GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.

Molecular and biochemical parasitology - 1 Aug 2016

Boitz Jan M, Jardim Armando, Ullman Buddy

Abstract excerpt

Purine acquisition is an essential nutritional process for Leishmania. Although purine salvage into adenylate nucleotides has been investigated in detail, little attention has been focused on the guanylate branch of the purine pathway. To characterize guanylate nucleotide metabolism in Leishmania and create a cell culture model in which the pathways for adenylate and guanylate nucleotide synthesis can be...

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Identifiers

PMID: 27343371
DOI: 10.1016/j.molbiopara.2016.06.008
PMCID: PMC5010971

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GMPR

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