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Article

S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers.

The Journal of biological chemistry - 22 Feb 2002

Roberts Sigrid C, Scott Jerry, Gasteier Judith E, Jiang Yuqui, Brooks Benjamin, Jardim Armando, Carter Nicola S, Heby Olle, Ullman Buddy

Abstract excerpt

The polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (ADOMETDC) has been advanced as a potential target for antiparasitic chemotherapy. To investigate the importance of this protein in a model parasite, the gene encoding ADOMETDC has been cloned and sequenced from Leishmania donovani. The Delta adometdc null mutants were created in the insect vector form of the parasite by double targeted gene...

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PMID: 11734561
DOI: 10.1074/jbc.M110118200

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