Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis.

Scientific reports - 2 Jun 2015

Anand Sneha, Madhubala Rentala

Abstract excerpt

Visceral leishmaniasis caused by Leishmania donovani is the most severe systemic form of the disease. There are still no vaccines available for humans and there are limitations associated with the current therapeutic regimens for leishmaniasis. Recently, we reported functional importance of Arabino-1, 4-lactone oxidase (ALO) enzyme from L. donovani involved in ascorbate biosynthesis pathway. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Protozoan
Share to Antigens, Protozoan

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ascorbic Acid

Share to Immunization

Share to Leishmania donovani

Share to Leishmaniasis, Visceral

Share to Nitric Oxide

Share to Parasite Load

Source

Open in PubMed Open full text

Identifiers

PMID: 26035062
DOI: 10.1038/srep10706
PMCID: PMC4451804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis.PMID 26035062Read ↗

Reduced pathogenicity of fructose-1,6-bisphosphatase deficient Leishmania donovani and its use as an attenuated strain to induce protective immunogenicity.Semantic proximity Read ↗

Ascorbate peroxidase from Leishmania major controls the virulence of infective stage of promastigotes by regulating oxidative stress.Semantic proximity Read ↗

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.Semantic proximity Read ↗

Ascorbate peroxidase modulation confirms key role in Leishmania infantum oxidative defenceSemantic proximity Read ↗

Genetically modified live attenuated vaccine: A potential strategy to combat visceral leishmaniasisSemantic proximity Read ↗

Adenine Aminohydrolase from Leishmania donovaniSemantic proximity Read ↗

Centrin-deficient <i>Leishmania mexicana</i> confers protection against Old World visceral leishmaniasisSemantic proximity Read ↗

Screening Leishmania donovani complex-specific genes required for visceral disease.Semantic proximity Read ↗

MVA-LACK as a safe and efficient vector for vaccination against leishmaniasisSemantic proximity Read ↗

Genetic analysis of Leishmania donovani tropism using a naturally attenuated cutaneous strain.Semantic proximity Read ↗

Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated LeishmaniaSemantic proximity Read ↗

Arginase activity in pathogenic and non-pathogenic species of Leishmania parasitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.