Article
IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.
Molecular and biochemical parasitology - 1 Dec 2011
Fulwiler Audrey L, Boitz Jan M, Gilroy Caslin, Yates Phillip A, Jardim Armando, Ullman Buddy
Abstract excerpt
Leishmania cannot synthesize purines de novo and therefore must scavenge purines from its host for survival and growth. Biochemical and genomic analyses have indicated that Leishmania species express three potential routes for the synthesis of guanylate nucleotides: (1) a two-step pathway that converts IMP to GMP; (2) a three-step pathway that starts with the deamination of guanine to xanthine, followed by...
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