HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

doi:10.1158/1055-9965.EPI-12-1000-T

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Article

HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2013

Laitinen Virpi H, Wahlfors Tiina, Saaristo Leena, Rantapero Tommi, Pelttari Liisa M, Kilpivaara Outi, Laasanen Satu-Leena, Kallioniemi Anne, Nevanlinna Heli, Aaltonen Lauri, Vessella Robert L, Auvinen Anssi, Visakorpi Tapio, Tammela Teuvo L J, Schleutker Johanna

Abstract excerpt

BACKGROUND: A recently identified germline mutation G84E in HOXB13 was shown to increase the risk of prostate cancer. In a family-based analysis by The International Consortium for Prostate Cancer Genetics (ICPCG), the G84E mutation was most prevalent in families from the Nordic countries of Finland (22.4%) and Sweden (8.2%). METHODS: To further investigate the importance of G84E in the Finns, we determined its...

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PMID: 23292082
DOI: 10.1158/1055-9965.EPI-12-1000-T

Genes

HOXB13
BRCA1
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