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T7 RNA polymerases backed up by covalently trapped proteins catalyze highly error prone transcription.

The Journal of biological chemistry - 24 Feb 2012

Nakano Toshiaki, Ouchi Ryo, Kawazoe Junya, Pack Seung Pil, Makino Keisuke, Ide Hiroshi

Abstract excerpt

RNA polymerases (RNAPs) transcribe genes through the barrier of nucleoproteins and site-specific DNA-binding proteins on their own or with the aid of accessory factors. Proteins are often covalently trapped on DNA by DNA damaging agents, forming DNA-protein cross-links (DPCs). However, little is known about how immobilized proteins affect transcription. To elucidate the effect of DPCs on transcription, we...

Topics

Bacteriophage T7
Catalysis
DNA Damage
DNA Repair
DNA-Binding Proteins
DNA-Directed RNA Polymerases
Mutagenesis
Mutation
Transcription, Genetic
Viral Proteins

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Identifiers

PMID: 22235136
DOI: 10.1074/jbc.M111.318410
PMCID: PMC3307275

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