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Article

Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin.

British journal of clinical pharmacology - 1 Sept 1990

Zhou H H, Anthony L B, Wood A J, Wilkinson G R

Abstract excerpt

Studies were performed in 13 healthy subjects to determine whether treatment with rifampicin results in induction of the metabolism of mephenytoin. Daily dosing with 600 mg rifampicin for 22 days caused a three to eightfold increase in the 0-8 h urinary R/S ratio of mephenytoin following oral adm...

Topics

Adult
Female
Humans
Hydroxylation
Male
Mephenytoin
Middle Aged
Phenotype
Rifampin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2223426
DOI: 10.1111/j.1365-2125.1990.tb03799.x
PMCID: PMC1368151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2223426-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin.PMID 2223426Read ↗

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