Article
The induction effect of rifampicin on activity of mephenytoin 4'-hydroxylase related to M1 mutation of CYP2C19 and gene dose.
British journal of clinical pharmacology - 1 Jan 1998
Feng H J, Huang S L, Wang W, Zhou H H
Abstract excerpt
AIMS: To determine the induction effect of rifampicin on the activity of 4'-hydroxylase in poor metabolizers (PMs) with m1 mutation of S-mephenytoin 4'-hydroxylation and the relationship of the effect with gene dose. METHODS: Seven extensive metabolizers (EMs) of S-mephenytoin 4'-hydroxylation an...
Topics
- Adult
- Antibiotics, Antitubercular
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Humans
- Hydroxylation
- Male
- Mephenytoin
- Mixed Function Oxygenases
- Mutation
- Rifampin
- Stereoisomerism