Article
Phenobarbital induces the 2-hydroxylation of desipramine.
Therapeutic drug monitoring - 1 Feb 1996
Spina E, Avenoso A, Campo G M, Caputi A P, Perucca E
Abstract excerpt
The kinetics of a single oral dose of desipramine (DMI; 100 mg) were studied in eight epileptic patients chronically treated with phenobarbital (PB) and in eight drug-free healthy controls. All subjects were extensive metabolizers with respect to the genetically determined CYP2D6-related metaboli...
Topics
- Adult
- Anticonvulsants
- Antidepressive Agents, Tricyclic
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Desipramine
- Enzyme Induction
- Epilepsy
- Half-Life
- Humans
- Hydroxylation
- Male
- Mixed Function Oxygenases
- Phenobarbital
- Phenotype
- Polymorphism, Genetic