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Article

Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.

European journal of human genetics : EJHG - 1 May 2012

Gartland Alison, Skarratt Kristen K, Hocking Lynne J, Parsons Claire, Stokes Leanne, Jørgensen Niklas Rye, Fraser William D, Reid David M, Gallagher James A, Wiley James S

Abstract excerpt

The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms (SNP; c.151+1G>T, c.946G>A, c.1096C>G, c.1513A>C and c.1729T>A) and one gain-of-function SNP (c.489C>T). The purpose of this study was to determine whether the functional P2RX7 SNPs are associated with lumbar spine (LS) bone mineral density (BMD), a key determinant of...

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Identifiers

PMID: 22234152
DOI: 10.1038/ejhg.2011.245
PMCID: PMC3330223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.PMID 22234152Read ↗

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