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Article

Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures.

European journal of human genetics : EJHG - 1 Jun 2012

Jørgensen Niklas R, Husted Lise B, Skarratt Kristen K, Stokes Leanne, Tofteng Charlotte L, Kvist Torben, Jensen Jens-Erik B, Eiken Pia, Brixen Kim, Fuller Stephen, Clifton-Bligh Rory, Gartland Alison, Schwarz Peter, Langdahl Bente L, Wiley James S

Abstract excerpt

The purinergic P2X7 receptor has a major role in the regulation of osteoblast and osteoclast activity and changes in receptor function may therefore affect bone mass in vivo. The aim of this study was to determine the association of non-synonymous single-nucleotide polymorphisms in the P2RX7 gene to bone mass and fracture incidence in post-menopausal women. A total of 1694 women (aged 45-58) participating in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Osteoporosis, Postmenopausal

Share to Polymorphism, Single Nucleotide

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Share to Receptors, Purinergic P2X7

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Identifiers

PMID: 22274585
DOI: 10.1038/ejhg.2011.253
PMCID: PMC3355253

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