Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P2X7 receptors: role in bone cell formation and function.

Journal of molecular endocrinology - 1 Apr 2015

Agrawal Ankita, Gartland Alison

Abstract excerpt

The role of the P2X7 receptor (P2X7R) is being explored with intensive interest in the context of normal bone physiology, bone-related diseases and, to an extent, bone cancer. In this review, we cover the current understanding of P2X7R regulation of bone cell formation, function and survival. We will discuss how the P2X7R drives lineage commitment of undifferentiated bone cell progenitors, the vital role of P2X7R...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Bone Neoplasms
Share to Osteocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Purinergic P2X7

Share to Signal Transduction

Source

Identifiers

PMID: 25591582
DOI: 10.1530/JME-14-0226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P2X7 receptors: role in bone cell formation and function.PMID 25591582Read ↗

The effect of P2RX7 functional SNPs on osteoblast cell phenotype, function and signalling- roles in bone homeostasis and osteogenesis.Semantic proximity Read ↗

Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factorSemantic proximity Read ↗

Significance of P2X7 receptor variants to human health and disease.Semantic proximity Read ↗

P2X7 Receptor in Hematological MalignanciesSemantic proximity Read ↗

P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis.Semantic proximity Read ↗

Role of purinergic receptor polymorphisms in human bone.Semantic proximity Read ↗

The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitroSemantic proximity Read ↗

Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment.Semantic proximity Read ↗

P2X7 Variants in Oncogenesis.Semantic proximity Read ↗

P2X7: a growth-promoting receptor—implications for cancerSemantic proximity Read ↗

Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures.Semantic proximity Read ↗

Cancer Metabostemness and Metabolic Reprogramming via P2X7 ReceptorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.