Article
Evaluation of TRAF6 in a large multiancestral lupus cohort.
Arthritis and rheumatism - 1 Jun 2012
Namjou Bahram, Choi Chan-Bum, Harley Isaac T W, Alarcón-Riquelme Marta E, Kelly Jennifer A, Glenn Stuart B, Ojwang Joshua O, Adler Adam, Kim Kwangwoo, Gallant Caroline J, Boackle Susan A, Criswell Lindsey A, Kimberly Robert P, Brown Elizabeth E, Edberg Jeffrey, Alarcón Graciela S, Stevens Anne M, Jacob Chaim O, Gilkeson Gary S, Kamen Diane L, Tsao Betty P, Anaya Juan-Manuel, Kim Eun-Mi, Park So-Yeon, Sung Yoon-Kyoung, Guthridge Joel M, Merrill Joan T, Petri Michelle, Ramsey-Goldman Rosalind, Vilá Luis M, Niewold Timothy B, Martin Javier, Pons-Estel Bernardo A, Vyse Timothy J, Freedman Barry I, Moser Kathy L, Gaffney Patrick M, Williams Adrienne H, Comeau Mary E, Reveille John D, Kang Changwon, James Judith A, Scofield R Hal, Langefeld Carl D, Kaufman Kenneth M, Harley John B, Bae Sang-Cheol
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development. METHODS: Fifteen...
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