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Article

TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.

Immunogenetics - 1 Oct 2013

Perricone Carlo, Ciccacci Cinzia, Ceccarelli Fulvia, Di Fusco Davide, Spinelli Francesca Romana, Cipriano Enrica, Novelli Giuseppe, Valesini Guido, Conti Fabrizio, Borgiani Paola

Abstract excerpt

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. Although genetic factors confer susceptibility to the disease, only 15 % of the genetic contribution has been identified. TRAF3IP2 gene, associated with susceptibility to psoriatic arthritis and psoriasis, encodes for Act1, a negative regulator of adaptive immunity and a positive signaling adaptor in IL-17-mediated immune responses. The...

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PMID: 23836313
DOI: 10.1007/s00251-013-0717-6

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