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Role of Cytokines in Systemic Lupus Erythematosus: Recent Progress from GWAS and Sequencing

1 Jan 2012

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder, known to have a strong genetic component. Concordance between monozygotic twins is approximately 30-40%, which is 8-20 times higher than that of dizygotic twins. In the last decade, genome-wide approaches to understanding SLE have yielded many candidate genes, which are important to understanding the pathophysiology of the disease and potential...

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PMID: 22654485
DOI: 10.1155/2012/798924

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