Article
TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.
Oncotarget - 6 Oct 2015
Drube Sebastian, Weber Franziska, Göpfert Christiane, Loschinski Romy, Rothe Mandy, Boelke Franziska, Diamanti Michaela A, Löhn Tobias, Ruth Julia, Schütz Dagmar, Häfner Norman, Greten Florian R, Stumm Ralf, Hartmann Karin, Krämer Oliver H, Dudeck Anne, Kamradt Thomas
Abstract excerpt
NF-κB activation depends on the IKK complex consisting of the catalytically active IKK1 and 2 subunits and the scaffold protein NEMO. Hitherto, IKK2 activation has always been associated with IκBα degradation, NF-κB activation, and cytokine production. In contrast, we found that in SCF-stimulated primary bone marrow-derived mast cells (BMMCs), IKK2 is alternatively activated. Mechanistically, activated TAK1...
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