Article
Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.
The Journal of biological chemistry - 29 Jul 2005
Thiefes Axel, Wolter Sabine, Mushinski J Frederic, Hoffmann Elke, Dittrich-Breiholz Oliver, Graue Nadine, Dörrie Anneke, Schneider Heike, Wirth Dagmar, Luckow Bruno, Resch Klaus, Kracht Michael
Abstract excerpt
The inflammatory response is characterized by the induction (or repression) of hundreds of genes. The activity of many of these genes is controlled by MAPKs and the IkappaB kinase-NFkappaB pathway. To reveal the effects of blocking these pathways simultaneously, fibroblasts were infected with retroviruses encoding TAK1K63W, an inactive mutant of the protein kinase TAK1. Expression of this protein inhibited tumor...
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