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Article

The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation.

The Journal of biological chemistry - 2 Feb 2001

Holtmann H, Enninga J, Kalble S, Thiefes A, Dorrie A, Broemer M, Winzen R, Wilhelm A, Ninomiya-Tsuji J, Matsumoto K, Resch K, Kracht M

Abstract excerpt

Mechanisms of fulminant gene induction during an inflammatory response were investigated using expression of the chemoattractant cytokine interleukin-8 (IL-8) as a model. Recently we found that coordinate activation of NF-kappaB and c-Jun N-terminal protein kinase (JNK) is required for strong IL-8 transcription, whereas the p38 MAP kinase (MAPK) pathway stabilizes the IL-8 mRNA. It is unclear how these pathways...

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Source

Identifiers

PMID: 11050078
DOI: 10.1074/jbc.M004376200

Genes

TAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation.PMID 11050078Read ↗

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

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Multiple control of interleukin-8 gene expressionSemantic proximity Read ↗

TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.Semantic proximity Read ↗

Regulation of Interleukin-8 Gene ExpressionSemantic proximity Read ↗

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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.Semantic proximity Read ↗

TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils.Semantic proximity Read ↗

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