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Article

Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2012

Ciarimboli Giuliano, Lancaster Cynthia S, Schlatter Eberhard, Franke Ryan M, Sprowl Jason A, Pavenstädt Hermann, Massmann Vivian, Guckel Denise, Mathijssen Ron H J, Yang Wenjian, Pui Ching-Hon, Relling Mary V, Herrmann Edwin, Sparreboom Alex

Abstract excerpt

PURPOSE: Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents. EXPERIMENTAL DESIGN: Creatinine transport was studied in transfected HEK293 cells in vitro and in wild-type mice and age-matched organic cation transporter 1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22223530
DOI: 10.1158/1078-0432.CCR-11-2503
PMCID: PMC3288323

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