Article

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

2022-05-13

Abstract excerpt

Study of renal transporters is crucial for understanding drug disposition and toxicity, and more importantly, predicting potential drug-drug interactions (DDIs). However, conventional in vitro models often fail to predict renal transporter activity and are not scalable to a predictive clinical outcome due to in vitro-in vivo discrepancy. Here, we successfully developed a human Proximal Tubule Kidney-Chip model t...

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Literature Corpus work: 2f6dbcbc-5e87-52e4-bb1f-ee18e8b3a425
DOI: 10.1101/2022.05.12.491717

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