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Article

Interaction of Cisplatin with the human organic cation transporter 2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2008

Filipski Kelly K, Loos Walter J, Verweij Jaap, Sparreboom Alex

Abstract excerpt

PURPOSE: Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation transporter 2 (OCT2) is highly expressed in the basolateral membrane of proximal tubules, we determined its contribution to cisplatin transport and assessed the relation of variation in the gene encoding OCT2 (SLC22A2) with the disposition of cisplatin. EXPERIMENTAL DESIGN: Cell lines were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18559608
DOI: 10.1158/1078-0432.CCR-07-4793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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