Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events.

Clinical and experimental nephrology - 1 Dec 2012

Iwata Kazufumi, Aizawa Keiji, Kamitsu Saori, Jingami Sachiko, Fukunaga Eiko, Yoshida Minoru, Yoshimura Misato, Hamada Akinobu, Saito Hideyuki

Abstract excerpt

BACKGROUND: Susceptibility to cisplatin (CDDP) nephrotoxicity is known to vary between individuals, but the basis of this variation has not been fully elucidated. In the kidney, CDDP is taken up into the renal proximal tubular cells mainly via SLC22A2 organic cation transporter 2 (OCT2) and secreted into lumen via other transporters including SLC47A1 multidrug and toxin extrusion 1 (MATE1). Here, we explore the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Glomerular Filtration Rate

Share to Incidence

Share to Organic Cation Transport Proteins

Share to Organic Cation Transporter 2

Share to Renal Insufficiency

Source

Identifiers

PMID: 22569819
DOI: 10.1007/s10157-012-0638-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events.PMID 22569819Read ↗

Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.Semantic proximity Read ↗

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug DispositionSemantic proximity Read ↗

Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.Semantic proximity Read ↗

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.Semantic proximity Read ↗

Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving CisplatinSemantic proximity Read ↗

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.Semantic proximity Read ↗

Genetic variation in organic cation transporters and considerations in drug development.Semantic proximity Read ↗

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.Semantic proximity Read ↗

Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K.Semantic proximity Read ↗

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics.Semantic proximity Read ↗

Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.Semantic proximity Read ↗

Multidrug and toxin extrusion 1 and human organic cation transporter 1 polymorphisms in patients with castration-resistant prostate cancer receiving metformin (SAKK 08/09).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.