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Article

Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study.

Blood - 23 Feb 2012

Campos Marco, Buchanan Ashley, Yu Fuli, Barbalic Maja, Xiao Yang, Chambless Lloyd E, Wu Kenneth K, Folsom Aaron R, Boerwinkle Eric, Dong Jing-fei

Abstract excerpt

Factor VIII (FVIII) functions as a cofactor for factor IXa in the contact coagulation pathway and circulates in a protective complex with von Willebrand factor (VWF). Plasma FVIII activity is strongly influenced by environmental and genetic factors through VWF-dependent and -independent mechanisms. Single nucleotide polymorphisms (SNPs) of the coding and promoter sequence in the FVIII gene have been extensively...

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Source

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Identifiers

PMID: 22219226
DOI: 10.1182/blood-2011-10-383661
PMCID: PMC3293647

Genes

VWF
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study.PMID 22219226Read ↗

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Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.Semantic proximity Read ↗

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