Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans.

doi:10.1002/ajh.24005

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Article

Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans.

American journal of hematology - 1 Jun 2015

Tang Weihong, Cushman Mary, Green David, Rich Stephen S, Lange Leslie A, Yang Qiong, Tracy Russell P, Tofler Geoffrey H, Basu Saonli, Wilson James G, Keating Brendan J, Weng Lu-Chen, Taylor Herman A, Jacobs David R, Delaney Joseph A, Palmer Cameron D, Young Taylor, Pankow James S, O'Donnell Christopher J, Smith Nicholas L, Reiner Alexander P, Folsom Aaron R

Abstract excerpt

Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and VWF are not well understood, especially in non European-American populations. We performed a...

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Identifiers

PMID: 25779970
DOI: 10.1002/ajh.24005
PMCID: PMC4747096

Genes

VWF
ABO
KNG1
TMLHE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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