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Article

Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Jan 2008

Trinh Kien, Moore Katherine, Wes Paul D, Muchowski Paul J, Dey Joyoti, Andrews Laurie, Pallanck Leo J

Abstract excerpt

Alpha-synuclein aggregates are a common feature of sporadic Parkinson's disease (PD), and mutations that increase alpha-synuclein abundance confer rare heritable forms of PD. Although these findings suggest that alpha-synuclein plays a central role in the pathogenesis of this disorder, little is known of the mechanism by which alpha-synuclein promotes neuron loss or the factors that regulate alpha-synuclein...

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Identifiers

PMID: 18184789
DOI: 10.1523/JNEUROSCI.4778-07.2008
PMCID: PMC6670551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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