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Article

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011

Liu Wencheng, Acín-Peréz Rebeca, Geghman Kindiya D, Manfredi Giovanni, Lu Bingwei, Li Chenjian

Abstract excerpt

Mutations in PTEN-induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. To investigate the mechanism of PINK1 pathogenesis, we used the Drosophila Pink1 knockout (KO) model. In mitochondria isolated from Pink1-KO flies, mitochondrial respiration driven by the electron transport chain (ETC) is significantly reduced. This reduction is the...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21768365
DOI: 10.1073/pnas.1107332108
PMCID: PMC3150934

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.PMID 21768365Read ↗

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