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Article

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2005

Whitworth Alexander J, Theodore Dorothy A, Greene Jessica C, Benes Helen, Wes Paul D, Pallanck Leo J

Abstract excerpt

Loss-of-function mutations of the parkin gene are a major cause of early-onset parkinsonism. To explore the mechanism by which loss of parkin function results in neurodegeneration, we are using a genetic approach in Drosophila. Here, we show that Drosophila parkin mutants display degeneration of a subset of dopaminergic (DA) neurons in the brain. The neurodegenerative phenotype of parkin mutants is enhanced by...

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Identifiers

PMID: 15911761
DOI: 10.1073/pnas.0501078102
PMCID: PMC1142368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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