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Article

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants.

PLoS genetics - 1 Jan 2012

Vilain Sven, Esposito Giovanni, Haddad Dominik, Schaap Onno, Dobreva Mariya P, Vos Melissa, Van Meensel Stefanie, Morais Vanessa A, De Strooper Bart, Verstreken Patrik

Abstract excerpt

Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery. Pink1 loss also affects the enzymatic activity of isolated Complex I of the electron transport chain (ETC); however, the primary defect in pink1 mutants is unclear. We tested the hypothesis that ETC...

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Identifiers

PMID: 22242018
DOI: 10.1371/journal.pgen.1002456
PMCID: PMC3252300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants.PMID 22242018Read ↗

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