Article
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 2010
Hao Ling-Yang, Giasson Benoit I, Bonini Nancy M
Abstract excerpt
Mutations or deletions in PARKIN/PARK2, PINK1/PARK6, and DJ-1/PARK7 lead to autosomal recessive parkinsonism. In Drosophila, deletions in parkin and pink1 result in swollen and dysfunctional mitochondria in energy-demanding tissues. The relationship between DJ-1 and mitochondria, however, remains unclear. We now report that Drosophila and mouse mutants in DJ-1 show compromised mitochondrial function with age....
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