Article
The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1).
Molecular and cellular biology - 1 May 2011
Saini Nidhi, Georgiev Oleg, Schaffner Walter
Abstract excerpt
The gene for Parkin, an E3 ubiquitin ligase, is mutated in some familial forms of Parkinson's disease, a severe neurodegenerative disorder. A homozygous mutant of the Drosophila ortholog of human parkin is viable but results in severe motoric impairment including an inability to fly, female and male sterility, and a decreased life span. We show here that a double mutant of the genes for Parkin and the...
Topics
- Animals
- Animals, Genetically Modified
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Homeostasis
- Male
- Metallothionein
- Metals
- Microscopy, Electron, Transmission