Article
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.
Organic & biomolecular chemistry - 7 Jan 2003
Sorensen John L, Auclair Karine, Kennedy Jonathan, Hutchinson C Richard, Vederas John C
Abstract excerpt
Two mutants of Aspergillus terreus with either the lovC or lovA genes disrupted were examined for their ability to transform nonaketides into lovastatin 1, a cholesterol-lowering drug. The lovC disruptant was able to efficiently convert dihydromonacolin L 5 or monacolin J 9 into 1, and could also transform desmethylmonacolin J 15 into compactin 3. In contrast, the lovA mutant has an unexpectedly active...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.