Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational biosynthesis of neomycin analogs by a mutant of neomycin-producing Streptomyces fradiae.

Folia microbiologica - 1 Nov 2011

Shi Guanying, Zhang Xingang, Wu Lang, Xie Jin, Tao Ke, Hou Taiping

Abstract excerpt

Neomycin, produced by Streptomyces fradiae, has been widely used for the treatment of bacterial infections in clinical and agricultural applications. In this study, a neomycin nonproducing mutant of S. fradiae was obtained by gene disruption technique for mutational biosynthesis. A crucial gene neoC (neo7) which encodes 2-deoxystreptamine (2-DOS) synthases was disrupted. The mutant could resume producing neomycin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins
Share to Molecular Structure

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neomycin

Share to Streptomyces

Source

Identifiers

PMID: 22083789
DOI: 10.1007/s12223-011-0082-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational biosynthesis of neomycin analogs by a mutant of neomycin-producing Streptomyces fradiae.PMID 22083789Read ↗

Characterization of RbmD (glycosyltransferase in ribostamycin gene cluster) through neomycin production reconstituted from the engineered Streptomyces fradiae BS1.Semantic proximity Read ↗

Improvement of amphotericin B production by a newly isolated Streptomyces nodosus mutant.Semantic proximity Read ↗

Substantial improvement of toyocamycin production in Streptomyces diastatochromogenes by cumulative drug-resistance mutations.Semantic proximity Read ↗

The three‐dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycinSemantic proximity Read ↗

Bioinformatics analysis of genes of Streptomyces xinghaiensis (fradiae) ATCC 19609 with a focus on mutations conferring resistance to oligomycin A and its derivatives.Semantic proximity Read ↗

New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.Semantic proximity Read ↗

Production of nikkomycins Bx and Bz by mutasynthesis with genetically engineered Streptomyces tendae Tü901.Semantic proximity Read ↗

Screening of mutant strain Streptomyces mediolani sp. AC37 for (-)-8-O-methyltetrangomycin production enhancement.Semantic proximity Read ↗

[Selection of ningnanmycin overproduction strains by resistance of self-secondary metabolites].Semantic proximity Read ↗

Activation of dormant secondary metabolite production by introducing neomycin resistance into the deep-sea fungus, Aspergillus versicolor ZBY-3.Semantic proximity Read ↗

Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities.Semantic proximity Read ↗

The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.