Article
Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.
Nucleic acids research - 2 Aug 2006
Pye Deborah, Kyriakouli Dimitra S, Taylor Geoffrey A, Johnson Riem, Elstner Matthias, Meunier Brigitte, Chrzanowska-Lightowlers Zofia M A, Taylor Robert W, Turnbull Douglass M, Lightowlers Robert N
Abstract excerpt
The human mitochondrial genome (mtDNA) encodes polypeptides that are critical for coupling oxidative phosphorylation. Our detailed understanding of the molecular processes that mediate mitochondrial gene expression and the structure-function relationships of the OXPHOS components could be greatly improved if we were able to transfect mitochondria and manipulate mtDNA in vivo. Increasing our knowledge of this...
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