Article
The A8296G mtDNA mutation associated with several mitochondrial diseases does not cause mitochondrial dysfunction in cybrid cell lines.
Human mutation - 1 Mar 2002
Bornstein Belén, Mas Jose Antonio, Fernández-Moreno Miguel Angel, Campos Yolanda, Martín Miguel Angel, del Hoyo Pilar, Rubio Juan Carlos, Arenas Joaquín, Garesse Rafael
Abstract excerpt
Transmitochondrial cybrid cell lines homoplasmic for the A8296G mtDNA transition, a mutation associated with several mitochondrial diseases, have a normal oxidative phosphorylation function, as shown by oxygen consumption, lactate production, respiratory enzyme activities, and growth using galactose as the only source of energy. The synthesis of mitochondrial proteins is also similar in mutant and wild-type...
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