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Article

Characterization of cybrid cell lines containing mtDNA from Huntington's disease patients.

Biochemical and biophysical research communications - 11 Aug 1999

Swerdlow R H, Parks J K, Cassarino D S, Shilling A T, Bennett J P, Harrison M B, Parker W D

Abstract excerpt

Electron transport chain (ETC) dysfunction may arise from mitochondrial genetic, nuclear genetic, or toxic etiologies. Cytoplasmic hybrid (cybrid) systems can help distinguish between these possibilities by facilitating expression of suspect mitochondrial DNA (mtDNA) within a nuclear and environmentally controlled context. Perpetuation of ETC dysfunction in cybrids is consistent with an mtDNA pathogenesis while...

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Identifiers

PMID: 10441489
DOI: 10.1006/bbrc.1999.1095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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