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Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA.

Biochimica et biophysica acta - 1 Jan 2000

Sato Akitsugu, Nakada Kazuto, Hayashi Jun-Ichi

Abstract excerpt

In mammalian cells, there is an extensive and continuous exchange of mitochondrial DNA (mtDNA) and its products between mitochondria. This mitochondrial complementation prevents individuals from expression of respiration deficiency caused by mutant mtDNAs. Thus, the presence of mitochondrial complementation does not support the generally accepted mitochondrial theory of aging, which proposes that accumulation of...

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PMID: 16624428
DOI: 10.1016/j.bbamcr.2006.03.001

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