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Article

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2003

Westlind-Johnsson Anna, Malmebo Sarah, Johansson Anna, Otter Charlotta, Andersson Tommy B, Johansson Inger, Edwards Robert J, Boobis Alan R, Ingelman-Sundberg Magnus

Abstract excerpt

To study mechanisms behind the interindividual variability in CYP3A expression and the relative contribution of the different CYP3A enzymes to the overall CYP3A activity, we have analyzed CYP3A4, CYP3A5, CYP3A43, and PXR mRNA and CYP3A4 and CYP3A5 protein expression, catalytic activity, and polymorphism in the CYP3A5 gene in a panel of 46 Caucasian human livers. Protein quantification was performed by Western...

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Identifiers

PMID: 12756208
DOI: 10.1124/dmd.31.6.755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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