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Article

Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Mar 2011

de Denus Simon, Zakrzewski Marcin, Barhdadi Amina, Leblanc Marie-Hélène, Racine Normand, Bélanger François, Carrier Michel, Ducharme Anique, Dubé Marie-Pierre, Turgeon Jacques, White Michel

Abstract excerpt

BACKGROUND: The renal expression of the cytochrome P450 3A5 (CYP3A5) isoenzyme and of the adenosine triphosphate (ATP)-binding cassette (ABC) efflux transporter P-glycoprotein is inversely associated with calcineurin-induced nephrotoxicity. The aim of this study was to evaluate the association be...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21094057
DOI: 10.1016/j.healun.2010.09.015

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21094057-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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