Article
Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy.
Rheumatology (Oxford, England) - 1 May 2012
Chinoy Hector, Li Charles K-C, Platt Hazel, Fertig Noreen, Varsani Hemlata, Gunawardena Harsha, Betteridge Zoe, Oddis Chester V, McHugh Neil J, Wedderburn Lucy R, Ollier William E R, Cooper Robert G
Abstract excerpt
OBJECTIVE: Treatment-resistant muscle wasting is an increasingly recognized problem in idiopathic inflammatory myopathy (IIM). TNF-α is thought to induce muscle catabolism via activation of nuclear factor-kappa B (NF-κB). Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM. METHODS: Data from 362 IIM...
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