Article
Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.
Annals of the rheumatic diseases - 1 Jul 2019
Rothwell Simon, Chinoy Hector, Lamb Janine A, Miller Frederick W, Rider Lisa G, Wedderburn Lucy R, McHugh Neil J, Mammen Andrew L, Betteridge Zoe E, Tansley Sarah L, Bowes John, Vencovský Jiří, Deakin Claire T, Dankó Katalin, Vidya Limaye, Selva-O'Callaghan Albert, Pachman Lauren M, Reed Ann M, Molberg Øyvind, Benveniste Olivier, Mathiesen Pernille R, Radstake Timothy R D J, Doria Andrea, de Bleecker Jan, Lee Annette T, Hanna Michael G, Machado Pedro M, Ollier William E, Gregersen Peter K, Padyukov Leonid, O'Hanlon Terrance P, Cooper Robert G, Lundberg Ingrid E
Abstract excerpt
OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement. The strongest genetic risk is within the major histocompatibility complex (MHC). Since autoantibody presence defines specific clinical subgroups of IIM, we aimed to correlate serotype and genotype, to identify novel risk variants...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.