Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat.

The American journal of pathology - 1 Oct 1990

Jiang Z, Handler E S, Rossini A A, Woda B A

Abstract excerpt

Insulin-dependent diabetes mellitus appears to be an autoimmune disease that is characterized morphologically by insulitis, an inflammation of the pancreatic islets of Langerhans that results in the destruction of the insulin-producing beta cells. The RT6-depleted DR rat provides a good model for the in situ study of insulitis. The authors used the anti-RT6.1 monoclonal antibody to selectively deplete RT6 T cells...

Topics

Animals
Antibodies, Monoclonal
Diabetes Mellitus, Experimental
Histocompatibility Antigens
Immunoenzyme Techniques
Inflammation
Islets of Langerhans
Lymphocyte Depletion
Macrophages
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Mutant Strains

T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 2221011
PMCID: PMC1877539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2221011-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat.PMID 2221011Read ↗

T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.Semantic proximity Read ↗

Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.Semantic proximity Read ↗

The Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+ Cell Infiltrations to Delay Diabetes in Congenic BB DRLyp/Lyp Rats.Semantic proximity Read ↗

Phenotypic characterization of mononuclear inflammatory cells in salivary glands of bio-breeding rats.Semantic proximity Read ↗

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.Semantic proximity Read ↗

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.Semantic proximity Read ↗

Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.Semantic proximity Read ↗

Gamma interferon prevents diabetes in the BB rat.Semantic proximity Read ↗

T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes.Semantic proximity Read ↗

Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.