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Article

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

The American journal of pathology - 1 Dec 1994

Doukas J, Mordes J P, Swymer C, Niedzwiecki D, Mason R, Rozing J, Rossini A A, Greiner D L

Abstract excerpt

We report an association between thymic epithelial defects and predisposition to autoimmunity. Diabetes-prone (DP) BB rats develop spontaneous hyperglycemia and are deficient in T cell subsets expressing the RT6 alloantigen. Diabetes resistant (DR) BB rats become diabetic if depleted of RT6+ T ce...

Topics

Aging
Animals
Animals, Newborn
Autoimmune Diseases
Autoimmunity
Epithelium
Genes, Dominant
Genetic Predisposition to Disease
Phenotype
Rats
Rats, Inbred BB
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reference Values

T-Lymphocytes

Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 7992854
PMCID: PMC1887500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7992854-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Thymic epithelial defects and predisposition to autoimmune disease in BB rats.PMID 7992854Read ↗

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