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Article

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

The American journal of pathology - 1 Dec 1994

Doukas J, Mordes J P, Swymer C, Niedzwiecki D, Mason R, Rozing J, Rossini A A, Greiner D L

Abstract excerpt

We report an association between thymic epithelial defects and predisposition to autoimmunity. Diabetes-prone (DP) BB rats develop spontaneous hyperglycemia and are deficient in T cell subsets expressing the RT6 alloantigen. Diabetes resistant (DR) BB rats become diabetic if depleted of RT6+ T cells. The inciting immune system defects are unknown. We made the following observations: 1) Regions of thymic cortex...

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Identifiers

PMID: 7992854
PMCID: PMC1887500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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