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Article

Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.

The Journal of biological chemistry - 17 Feb 2012

Lan Hsin-Chieh, Wu Chih-Feng, Shih Hsiu-Ming, Chung Bon-Chu

Abstract excerpt

SF-1 is a key transcription factor for all steroidogenic genes. It up-regulates the expression of the steroidogenic Cyp11a1 gene in the adrenal in a pathway stimulated by cAMP through HIPK3-mediated JNK/c-Jun phosphorylation. In the present study, we have investigated the factors mediating cAMP-dependent HIPK3 action to potentiate the activity of SF-1 for Cyp11a1 transcription in mouse adrenocortical Y1 cells. We...

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Source

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Identifiers

PMID: 22199361
DOI: 10.1074/jbc.M111.307603
PMCID: PMC3285359

Genes

HIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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