Article

Functions of the Upstream and Proximal Steroidogenic Factor 1 (SF-1)-Binding Sites in the CYP11A1 Promoter in Basal Transcription and Hormonal Response

2001-05-01

Abstract excerpt

The CYP11A1 gene encodes P450scc (cholesterol side-chain cleavage enzyme), which catalyzes the first step for the synthesis of steroids. Expression of CYP11A1 is controlled by transcription factor SF-1 (steroidogenic factor 1). Two functional SF-1-binding sites, P and U, located at −40 and −1,600 regions of the CYP11A1 gene, have been identified, but their exact functions with respect to basal activation vs. cAMP...

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Literature Corpus work: abd6b2b2-8e0e-558b-b1c0-1fc51baa5487
DOI: 10.1210/me.15.5.812

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