AGP/EBP(LAP) expressed in rat hepatoma cells interacts with multiple promoter sites and is necessary for maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene.

doi:10.1128/mcb.11.10.4959-4965.1991

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Article

AGP/EBP(LAP) expressed in rat hepatoma cells interacts with multiple promoter sites and is necessary for maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene.

Molecular and cellular biology - 1 Oct 1991

Williams P, Ratajczak T, Lee S C, Ringold G M

Abstract excerpt

Transcription of the rat alpha 1-acid glycoprotein (AGP) gene is induced by glucocorticoids. In addition to the glucocorticoid response element which maps to bases -120 to -107, sequences located between bases -106 to -42 have been shown to be necessary for hormone induction. We have previously identified multiple sites of C/EBP interaction with the AGP promoter in the region -106 to -64. In this study, we purify...

Topics

Animals
Base Sequence
Binding Sites
Blotting, Western
CCAAT-Enhancer-Binding Proteins
DNA-Binding Proteins
Dexamethasone
Gene Expression Regulation
Glucocorticoids
Glycoprotein Hormones, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms, Experimental

Molecular Sequence Data

Mutation

Nuclear Proteins

Orosomucoid

Promoter Regions, Genetic

Rats

Transcription Factors

Source

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Identifiers

PMID: 1717823
DOI: 10.1128/mcb.11.10.4959-4965.1991
PMCID: PMC361476

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717823-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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