Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.

Free radical biology & medicine - 1 Dec 2009

Lee Seung-Yon, Gong Eun-Yeung, Hong Cheol Yi, Kim Keon-Hee, Han Jung-Soo, Ryu Jae Chun, Chae Ho Zoon, Yun Chul-Ho, Lee Keesook

Abstract excerpt

Steroidogenesis decreases with aging in the testis, whereas the levels of reactive oxygen species (ROS) increase. In addition, ROS have been reported to inhibit testicular steroidogenesis. Here, we investigated the effects of ROS on the transcriptional activity of Nur77, one of the major transcription factors that regulate the expression of steroidogenic enzyme genes. ROS signaling inhibited Nur77...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthracenes
Share to Hydrogen Peroxide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leydig Cells

Share to MAP Kinase Kinase 4

Share to Proto-Oncogene Proteins c-jun

Share to Steroid 17-alpha-Hydroxylase

Share to Steroidogenic Acute Regulatory Protein

Share to Steroids

Source

Identifiers

PMID: 19751824
DOI: 10.1016/j.freeradbiomed.2009.09.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.PMID 19751824Read ↗

c-Jun N-terminal kinase signaling in agingSemantic proximity Read ↗

From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical ImportanceSemantic proximity Read ↗

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.Semantic proximity Read ↗

JNK signalling regulates antioxidant responses in neuronsSemantic proximity Read ↗

MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.Semantic proximity Read ↗

Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotropeSemantic proximity Read ↗

Nur77 transcription activity correlates with its apoptotic function in vivo.Semantic proximity Read ↗

Regulation of NGFI‐B/Nur77 gene expression in the rat ovary and in leydig tumor cells MA‐10Semantic proximity Read ↗

Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.Semantic proximity Read ↗

c-Jun/AP-1, but not NF-kappa B, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells.Semantic proximity Read ↗

C-Jun terminal kinases play an important role in regulating embryonic survival and eye development in vertebrates.Semantic proximity Read ↗

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.