CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP.

doi:10.1677/joe.1.06601

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Article

CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP.

The Journal of endocrinology - 1 Oct 2006

Sugawara Teruo, Sakuragi Noriaki, Minakami Hisanori

Abstract excerpt

Steroidogenic acute regulatory (StAR) protein plays a critical role in steroid hormone synthesis. Tropic hormones induce human StAR gene expression by a cAMP-dependent pathway. Steroidogenic factor-1/adrenal-4-binding protein (SF-1/Ad4BP) plays an important role in the expression of human StAR gene. We investigated the mechanism of cAMP responsiveness in human StAR gene expression in NCI-H295R cells. The StAR...

Topics

8-Bromo Cyclic Adenosine Monophosphate
Adrenal Cortex
Analysis of Variance
Blotting, Western
Cell Line, Tumor
Cyclic AMP
Cyclic AMP Response Element-Binding Protein
Gene Expression
Genetic Engineering
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Phosphoproteins

Promoter Regions, Genetic

RNA Interference

RNA, Small Interfering

Receptors, Cytoplasmic and Nuclear

Steroidogenic Factor 1

Source

Open in PubMed

Identifiers

PMID: 17065415
DOI: 10.1677/joe.1.06601

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