Article
Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17.
Endocrine research - 1 Jan 2000
Lund J, Jacob A, Aesöy R, Yri O E, Mellgren G
Abstract excerpt
Several lines of evidence have suggested that the nuclear receptor Steroidogenic Factor-1 (SF-1 or Ad4BP) may be directly involved in the cAMP-dependent regulation of steroid hydroxylase genes in adrenocortical cells. In the bovine CYP17 gene, which encodes the cytochrome P450 17alpha-hydroxylase...
Topics
- Adrenal Cortex Neoplasms
- Animals
- CREB-Binding Protein
- Cattle
- Cyclic AMP
- DNA-Binding Proteins
- Fushi Tarazu Transcription Factors
- Gene Deletion
- Genes, Dominant
- Histone Acetyltransferases
- Homeodomain Proteins
- Mice
- Mutation
- Nuclear Proteins
- Nuclear Receptor Coactivator 1
- Point Mutation
- Receptors, Cytoplasmic and Nuclear
- Steroid 17-alpha-Hydroxylase