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Article

Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17.

Endocrine research - 1 Jan 2000

Lund J, Jacob A, Aesöy R, Yri O E, Mellgren G

Abstract excerpt

Several lines of evidence have suggested that the nuclear receptor Steroidogenic Factor-1 (SF-1 or Ad4BP) may be directly involved in the cAMP-dependent regulation of steroid hydroxylase genes in adrenocortical cells. In the bovine CYP17 gene, which encodes the cytochrome P450 17alpha-hydroxylase, an SF-1 site is present within cAMP-responsive sequence 2 (CRS2) and mutations which interfere with SF-1 binding...

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PMID: 9888530
DOI: 10.3109/07435809809032638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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